PF-4178903 [CAS 1310796-72-5]

PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases[1].

[1310796-72-5]

C25H37F3N4O3

498.58

O=C(N1CCN(C2=CC(C(F)(F)F)=CC=N2)CC1)[C@@]3(C[C@@H](CC3)N[C@@H]4[C@@H](COCC4)OC)C(C)C

CCR

CCR2; CCR5

Room temperature