PF-4522654 [CAS 1065109-28-5]

PF-4522654 is a potent, selective and brain-permeable 5-HT2C receptor agonist with an EC50 of 16 nM and a Ki of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT2A and 5-HT2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI) [1].

[1065109-28-5]

C16H18F2N4

304.34

FC(C1=NC(CCNCC2)=C2C(NC)=N1)(C3=CC=CC=C3)F

5-HT Receptor

5-HT2 Receptor; α-1 microglobulin

Room temperature