PG01 [CAS 853138-65-5]

PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM) . PG01 increases ΔF508-CFTR Cl- current after adding Forskolin[1][2].

[853138-65-5]

C28H29N3O2

439.55

O=C(N(C)C(C1=CC=CC=C1)C(NC2=CC=C(C(C)C)C=C2)=O)CC3=CNC4=C3C=CC=C4

CFTR

10mM

98.04

DMSO : 43.96 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice

H302, H413

H302, H413