PH14

PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma[1].

C34H39N9O5

653.73

COC1=NC(N2CCOCC2)=NC(C3=CC=C(NC(NC4=CC=C(C(NCCCCCC(NC5=CC=CC=C5N)=O)=O)C=C4)=O)C=C3)=N1

Apoptosis; HDAC; PI3K

HDAC3; PI3Kα

99.29

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice