Phellodendrine [CAS 6873-13-8]

Phellodendrine is an orally active plant alkaloid. Phellodendrine inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway[1][2][3][4][5][6].

[6873-13-8]

C20H24NO4

342.41

OC1=C(OC)C=C2CC[N@@+]3(C)CC4=CC(OC)=C(O)C=C4C[C@@]3([H])C2=C1

Akt; AMPK; Apoptosis; Autophagy; COX; Interleukin Related; MMP; mTOR; NF-κB; p38 MAPK; PI3K; PKC; Reactive Oxygen Species (ROS) ; STAT

COX-2; IL-1; IL-6; MMP-3; mTOR; NF-κB; PI3K; STAT3

99.6

DMSO : 5 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature