Phenamil (methanesulfonate) [CAS 1161-94-0]

Phenamil methanesulfonate, an analog of Amiloride , is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM[2]. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay[1]. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway[4]. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease[5].

[1161-94-0]

C13H16ClN7O4S

401.83

O=C(C1=NC(Cl)=C(N)N=C1N)NC(NC2=CC=CC=C2)=N.CS(=O)(O)=O

Sodium Channel; TRP Channel

TRPC3

98.1

DMSO : 25 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice