Phenchlobenpyrrone [CAS 215036-81-0]

Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease[1].

[215036-81-0]

C17H16ClNO

285.77

O=C1N[C@@H]([C@H](C1)C2=CC=CC=C2)CC3=CC=CC=C3Cl

Amyloid-β; Calcium Channel; Cholinesterase (ChE) ; Tau Protein

Room temperature