Phlotoxin-1

Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].

C183H254N46O48S6

4058.64

O=C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C)=O)=O)=O)=O)NC4=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CC9=CC=C(C=C9)O)C(N%10[C@@H](CCC%10)C(N[C@H]%11CC%12=CNC%13=CC=CC=C%12%13)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(O)=O)C(N%14[C@@H](CCC%14)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC%16=CC=CC=C%16)C(O)=O)=O)=O)=O)=O)=O)NC%11=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Sodium Channel

10 mM in DMSO

Room temperature