PI4Kβ/PKG-IN-1

PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG) . PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria[1].

C19H13ClFN7O

409.8

NC1=NC2=CC(C3=NN(CC4=CC=C(Cl)C(F)=C4)C5=NC=NC(N)=C53)=CC=C2O1

Parasite; PI4K; PKG

Room temperature