PIK-75 [CAS 372196-67-3]

PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM) [1][2]. PIK-75 induces apoptosis[3].

[372196-67-3]

C16H14BrN5O4S

452.28

O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)/N=C/C2=CN=C3C=CC(Br)=CN32)=O

Apoptosis; DNA-PK; PI3K

PI3KC2α; PI3KC2β; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

10mM

99.94

DMSO : 13 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302+H312+H332, H315, H319, H335

H302+H312+H332, H315, H319, H335