PIM1-IN-8

PIM1-IN-8 is a PIM1/p65 pathway inhibitor. PIM1-IN-8 suppresses the expression of α-SMA and collagen I in activated fibroblasts and blocks TGF-β induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) -induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF).

C17H17NO4

299.32

O=C(NC1=CC(C(C)=O)=C(O)C=C1OC)C2=CC=CC(C)=C2

Interleukin Related; NF-κB; Pim

Room temperature