Pimethixene [CAS 314-03-4]

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

[314-03-4]

C19H19NS

293.43

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3

5-HT Receptor; Histamine Receptor

5-HT1 Receptor;5-HT2 Receptor; H1 Receptor; mLAG-3; α-1 microglobulin

10 mM in DMSO

Room temperature