(-) -Pimobendan [CAS 118428-37-8]

(-) -Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-) -pimobedan from erythrocytes is significantly lower than that of (+) -pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-) -pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+) -isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-) -pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.

[118428-37-8]

C19H18N4O2

334.37

O=C1CC(C)C(C2=CC=C3C(N=C(C4=CC=C(OC)C=C4)N3)=C2)=NN1.[Rotation(-)]

Phosphodiesterase (PDE)

Room temperature