PIN1 degrader-3 [CAS 3101950-55-1]

PIN1 degrader-3 is a Pin1 (peptidyl-prolyl isomerase protein) (IC50 = 4.65 nM) degrader. PIN1 degrader-3 bound covalently to Pin1. PIN1 degrader-3-induced Pin1 degradation reduced cell viability, with EC50 values after 72 h of 8.4 μM in MIA PaCa-2 cells and 5.3 μM in KPC cell lines.PIN1 degrader-3 can destabilize Pin1 in vitro, causing its degradation in cells. PIN1 degrader-3 can be used for the study of pancreatic cancer[1].

[3101950-55-1]

C31H34Cl2N6O4

625.55

O=C(NC)[C@@H](NC([C@@H]1CCCCN1C([C@@H](NC(CCl)=O)CC2=CNC3=C2C=CC(Cl)=C3)=O)=O)CC4=CNC5=C4C=CC=C5

PIN1

Room temperature