PK-10 [CAS 3074451-41-2]

PK-10 is a synergistic antibacterial agent of Fluconazole and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction[1].

[3074451-41-2]

C35H36F3N5O

599.69

O=C(C1=CC=C(N2CCN(CC2)CC3=CC=C(C(F)(F)F)C=C3)C=C1)/C=C/C4=CC5=C(N=C4N6CCN(CC6)C)C=CC=C5

Fungal; Mitochondrial Metabolism

10 mM in DMSO

Room temperature