PKM2-IN-8

PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC50 = 0.31 μM) . PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early apoptosis and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma[1].

C19H13N7O

355.35

O=C(CN1N=C(C2=CC=C(C=CC=C3)C3=C2)N=N1)C4=CN=C5N4C=CC=N5

Apoptosis; Pyruvate Kinase

Room temperature