PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1].
CAS Number
[2361545-75-5]
Molecular Formula
C18H17IN2O3
Molecular Weight
436.24
Smiles
IC1=CC2=NC=CC(NC3=CC(OC)=C(C(OC)=C3)OC)=C2C=C1
Target
PI3K
Purity
98.97
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)