Name: PKUMDL-WQ-2201 [CAS 592474-91-4]
Brand: QuantiMol
SKU: QM-0140862-01
Price: 118.38 GBP
Availability: InStock

Product Details

Description
PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM) . PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth[1][2].
CAS Number
[592474-91-4]
Molecular Formula
C15H14ClN3O3S
Molecular Weight
351.81
Smiles
O=C(C1=CC=C(C=C1Cl)C2=CC=C(O2)/C=N/NC(NCC)=S)O
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0140862-01	5 mgQM-0140862-01 £118.38/ea	£0.00	Quantity	£118.38/ea	£0.00

10 mM - 1 mLQM-0140862-02	10 mM - 1 mLQM-0140862-02 £127.38/ea	£0.00	Quantity	£127.38/ea	£0.00

10 mgQM-0140862-03	10 mgQM-0140862-03 £226.18/ea	£0.00	Quantity	£226.18/ea	£0.00

25 mgQM-0140862-04	25 mgQM-0140862-04 £426.65/ea	£0.00	Quantity	£426.65/ea	£0.00

50 mgQM-0140862-05	50 mgQM-0140862-05 £690.30/ea	£0.00	Quantity	£690.30/ea	£0.00

100 mgQM-0140862-06	100 mgQM-0140862-06 £1,128.92/ea	£0.00	Quantity	£1,128.92/ea	£0.00

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PKUMDL-WQ-2201 [CAS 592474-91-4]

PKUMDL-WQ-2201 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.