PNR-3-80 [CAS 1424353-63-8]

PNR-3-80 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.67 μM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a potent cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin and Docetaxel (HY-B0011) -induced cell death and represses Etoposide (HY-13629) -induced DNA damage and autophagy. PNR-3-80 can be used for cell injuries research[1][2].

[1424353-63-8]

C24H14ClN3O3S

459.9

O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(Cl)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S

Endonuclease

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature