PNU-159682 [CAS 202350-68-3]

PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

[202350-68-3]

C32H35NO13

641.62

COC1=C(C(C(C(O)=C([C@@H](O[C@H]2C[C@H]3[C@H](O[C@H]4N3CCO[C@@H]4OC)[C@H](C)O2)C[C@@](C(CO)=O)(O)C5)C5=C6O)=C6C7=O)=O)C7=CC=C1

ADC Payload; Topoisomerase

Daunorubicins/Doxorubicins; Topo I

98.57

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, stored under nitrogen)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335