Polθ-IN-4 [CAS 3043810-73-4]

Polθ-IN-4 is an orally active prodrug of a DNA polymerase θ (Polθ) inhibitor with Kms of 3.7, 3.7 and 5.2 μM in human, mouse and rat recombinant alkaline phosphatases. Polθ-IN-4 that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 demonstrates significant anti-tumor activity in multiple animal experiments. Polθ-IN-4 can be used for the studies of breast cancer and ovarian cancer[1].

[3043810-73-4]

C17H17ClN5O7PS

501.84

ClC1=NC=C(OC)C(C2=C(C(/N=C3N(COP(O)(O)=O)N=C(OC)S/3)=O)C=NC(C)=C2)=C1

DNA/RNA Synthesis

10mM

98.71

DMSO : 17.5 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature