Pomalidomide-PEG4-azide [CAS 2271036-47-4]

Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[2271036-47-4]

C23H30N6O8

518.52

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN=[N+]=[N-])=O

E3 Ligase Ligand-Linker Conjugates

Cereblon

99.85

DMSO : 31.25 mg/mL (ultrasonic)

-20°C (Powder, protect from light)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335