PQ32

PQ32 is an antitumor agent that targets c-MYC Pu27 and KRAS G-quadruplexes. PQ32 inhibits tumor cell proliferation, arrests the cell cycle at the G2 phase, and induces apoptosis. PQ32 inhibits the expression of c-MYC and KRAS genes. PQ32 can inhibit tumor growth in mice and is used in the study of lymphoma, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and other cancers[1].

C27H21N3O6

483.47

COC(C=CC(CN1C=C2C(C3=CC4=C(C=C3)OCO4)=NN=C2C5=C1C=C6OCOC6=C5)=C7)=C7OC

Apoptosis; c-Myc; Ras

K-Ras

Room temperature