PRMT1-IN-3 [CAS 892570-48-8]

PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with IC50s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel. PRMT1-IN-3 can be used for the study of TNBC[1].

[892570-48-8]

C18H23FN2O

302.39

FC1=CC=C(COC2=C(C=CC=C2)CNCCCNC)C=C1

Apoptosis; Histone Methyltransferase

PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8

Room temperature