PRMT5-IN-31

PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM) . PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min) [1].

C21H24N2O2

336.43

O[C@@H](CN1C=CC2=C1C=CC(OC)=C2)CN(C3)CCC4=C3C=CC=C4

Apoptosis; Histone Methyltransferase

10mM

99.25

DMSO : 50 mg/mL (ultrasonic)

4°C (Powder, protect from light, stored under nitrogen)

Room Temperature