PRO-6E [CAS 2353493-69-1]

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note: (Blue: Cereblon ligand , Black: linker; Pink: ALK/c-Met inhibitor Crizotinib (HY-50878) ).

[2353493-69-1]

C42H44Cl2FN7O7

848.75

O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O

Apoptosis; c-Met/HGFR; PROTACs

10mM

99.85

DMSO : ≥ 100 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature