Pro-FTY [CAS 3064707-13-4]

Pro-FTY, a FTY720 anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia[1].

[3064707-13-4]

C33H50N4O4

566.77

OCC(NC(OCC1=CC(C(C)C)=C(N=[N+]=[N-])C(C(C)C)=C1)=O)(CO)CCC2=CC=C(CCCCCCCC)C=C2

LPL Receptor; STAT

STAT3

Room temperature