Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].
CAS Number
[2222067-12-9]
Molecular Formula
C12H19NO7
Molecular Weight
289.28
Smiles
O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O
Target
Ferroptosis
Purity
97.86
Solubility
DMSO : 50 mg/mL (ultrasonic)
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)