Pro-PTX [CAS 3011748-20-9]

Pro-PTX is an inactive prodrug of Paclitaxel. Pro-PTX does not show cytotoxicity against cancer cells, such as A549, U87 and HBVP cells. Pro-PTX can be converted into Paclitaxel through dealkylation catalyzed by Pd nanosheets in agarose and alginate hydrogels[1].

[3011748-20-9]

C56H63N3O17

1050.11

CC1=C([C@@H](OC(C)=O)C([C@@]2(C)[C@]([C@@](CO3)(OC(C)=O)[C@@]3([H])C[C@@H]2O)([H])[C@@H]4OC(C5=CC=CC=C5)=O)=O)C(C)(C)[C@@]4(O)C[C@@H]1OC([C@H](OC(N(CCN(C(OCC#C)=O)C)C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7)=O

Drug Intermediate

Room temperature