Propoxur-d3 [CAS 1219798-56-7]

Propoxur-d3 is the deuterated form of Propoxur. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3][4].

[1219798-56-7]

C11H12D3NO3

212.26

O=C(NC([2H])([2H])[2H])OC1=C(OC(C)C)C=CC=C1

Cholinesterase (ChE) ; ERK; Insecticide; Isotope-Labeled Compounds; Keap1-Nrf2; MMP; Reactive Oxygen Species (ROS)

AChE; MMP-2

10 mM in DMSO

Room temperature