PROTAC ALK degrader-2

PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM in H3122 EML4-ALK DC50 (GSH+) . PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment[1].

C179H318ClN11O74S3

3940.12

O=S(C1=C(C=CC=C1)NC2=C(C=NC(NC3=C(C=C(C(C)=C3)C4CCN(CC4)CC(N(CC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)CCSSCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)=O)OC(C)C)=N2)Cl)(C(C)C)=O

Anaplastic lymphoma kinase (ALK) ; PROTACs

Room temperature