PROTAC ATR degrader-2 [CAS 3010273-12-5]

PROTAC ATR degrader-2 (Compound 8i) is a PROTAC degrader for ATR, through of. PROTAC ATR degrader-2 degrades ATR in acute myeloid leukemia (AML) cells MV-4-11 and MOLM-13, with DC50 of 22.9 and 34.5 nM. APROTAC ATR degrader-2 induces apoptosis, inhibits proliferations of AML cells. PROTAC ATR degrader-2 exhibits good pharmacokinetics charachers and antitumor efficacy against AML in mouse model. (Pink: ATR ligand ; Blue:E3 ligase ligand Lenalidomide (HY-A0003) ; Black: linker)

[3010273-12-5]

C40H41N9O6

743.81

O=C(C1=NC(C2=CC=C(C(N3CCN(CCCCC(NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC3)=O)C=C2)=CN=C1N)NC7=CC=CC=C7

Apoptosis; PROTACs

99.73

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature