PROTAC BCL-xL/BCL-w Degrader 1

PROTAC BCL-xL/BCL-w Degrader 1 (Compound 44) is a BCL-xL/BCL-w PROTAC degrader. PROTAC BCL-xL/BCL-w Degrader 1 has significant anticancer activity with reduced on-target platelet toxicity. Pink: BCL-xL/BCL-w ligand ; Blue: CRBN ligase ligand (HY-163233) ; Black: linker (HY-Y1230)

C69H77ClF3N9O10S3

1381.05

ClC(C=C1)=CC=C1C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C(C#CCCC(N8CCN(C9=CC=C(C(N(C%10CCC(NC%10=O)=O)C%11)=O)C%11=C9)CC8)=O)=C5)=O)=O)C=C4)CC3)CC(C)(C)CC2

Bcl-2 Family; PROTACs

Bcl-W; Bcl-xL

Room temperature