PROTAC Bcl-xL degrader-1 [CAS 2450351-07-0]

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively[1].

[2450351-07-0]

C76H96ClF3N10O11S3

1514.28

ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[C@H](NC([C@@H]9C(C)(C[C@@]([H])(N9C%10=O)OCC[C@@H]%10NC([C@@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O

Bcl-2 Family; PROTACs

Bcl-xL; cIAP1

10 mM in DMSO

Room temperature