PROTAC BRD4 Degrader-36

PROTAC BRD4 Degrader-36 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-36 has a DC50 of 0.649 nM and a Dmax of 71% in PANC-1 cells. PROTAC BRD4 Degrader-36 is cytotoxic to PANC-1 cells (GI50: 0.103 μM). PROTAC BRD4 Degrader-36 can be used in the study of cancer. (Pink: PROTAC BRD4 ligand-1 ; Blue + Black: E3 ligase ligand + linker (HY-175241) ).

C52H58F2N6O7S3

1013.24

O=C(C1=C(C=C2C3=CN(C(C4=C3C(CN(C2=C1)C5=NC=C(C=C5F)F)=CN4)=O)C)CS(C)(=O)=O)NCCCCCCCN(CC6CCCCC6)C(C7=C(S(=O)(C)=O)C=C(C=C7)C8=CC=CC=C8SC)=O

Epigenetic Reader Domain; PROTACs

BRD4

Room temperature