PROTAC BRD4 Degrader-37

PROTAC BRD4 Degrader-37 (Compound TrimTAC-2) is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-37 has a DC50 of 36.4 nM and a Dmax of 73% in PANC-1 cells. PROTAC BRD4 Degrader-37 exhibits cytotoxicity against PANC-1 cells (GI50: 0.282 μM). PROTAC BRD4 Degrader-37 can be used in the research of tumors. (Pink: PROTAC BRD4 ligand-4 ; Blue + Black: E3 ligase ligand + linker (HY-175241) ).

C46H55N3O6S2

810.08

CSC1=CC=CC=C1C2=CC(S(C)(=O)=O)=C(C=C2)C(N(CC3CCCCC3)CCCCCCCNC(C4=CC5=C(C(C)=CC(C6=CN(C(C(C)=C6)=O)C)=C5)O4)=O)=O

Epigenetic Reader Domain; PROTACs

BRD4

Room temperature