PROTAC BRD4 Degrader-40

PROTAC BRD4 Degrader-40 is a Bromodomain protein 4 (BRD4) PROTAC degrader. PROTAC BRD4 Degrader-40 can induce BRD4 degradation in cancer cells. PROTAC BRD4 Degrader-40 can be used for the research of cancer, such as leukemia[1]. (Structure Note: Pink: BRD4 ligand ; Blue: CRBN ligand (HY-163927) )

C39H34ClN9O4S

760.26

O=C(N/N=C\C1=CC=C(C2=C(N3C)C(N(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)C=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5

Epigenetic Reader Domain; PROTACs

BRD4; Cereblon

Room temperature