PROTAC BRM/BRG1 degrader-1 [CAS 2724268-88-4]

PROTAC BRM/BRG1 degrader-1 (Example 253) is a PROTAC BRM/BRG1 degrader, with DC50 of 10-100 nM for BRM, > 1 μM for BRG1. PROTAC BRM/BRG1 degrader-1 can be used for cancer research. Blue: E3 ligase ligand , black: linker (HY-168244). Red: BRM/BRG1 inhibitor (HY-W539427).

[2724268-88-4]

C54H63N9O9S

1014.2

NC(N=NC(C1=C(O)C=CC=C1)=C2)=C2OCCC3=CC=C(C(N4CC(OC5CCN(CCOC6=NOC([C@@H](C(C)C)C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=C6)CC5)C4)=O)C=C3

Epigenetic Reader Domain; PROTACs

Room temperature