PROTAC BRM/BRG1 degrader-4

PROTAC BRM/BRG1 degrader-4 (example 047) is a potent BRM and BRG1 PROTAC degrader, with DC50 values of 0.21 nM and 3.4 nM in SW1573 cells, respectively (Pink: ligand for target protein ; Black: linker (HY-28911) ; Blue: E3 ligase ligand (HY-168253) ).

C44H52N10O6S

849.01

CNC(C1=C2C=C(C3=C(O)C=CC=C3)N=N1)=NN2C4CCN(CCOC5=NOC(C(C(N6C[C@H](O)C[C@H]6C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)C(C)C)=C5)CC4

Epigenetic Reader Domain; PROTACs

Room temperature