PROTAC BTK Degrader-12 [CAS 2736508-65-7]

PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader (Pink & black: BTK ligand & linker ; Black: linker (HY-30105) ; Blue: CRBN ligand (HY-W245311) ).

[2736508-65-7]

C47H54N12O4

851.01

CC(C)(C)C1=NOC(C(N[C@@H](C2=CC=C(C3=C4C(NC(C5=NC=C(N6CCN(CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)CC6)C=C5)=C4)=NC=N3)C=C2C)C)=O)=N1

Btk; PROTACs

Cereblon

Room temperature