PROTAC CYP1B1 degrader-2 [CAS 2836297-26-6]

PROTAC CYP1B1 degrader-2 (compound PV2) is a von Hippel-Landau (VHL) E3 ligase-based CYP1B1 degrader with the DC50 of 1.0 nM at 24 h in A549/Taxol cells. PROTAC CYP1B1 degrader-2 inhibits growth, migration, and invasion of A549/Taxol cell (Sturcture Note: (Blue: VHL ligand , Black: linker (HY-W007700), Pink: CYP1B1 ligand (HY-159006).

[2836297-26-6]

C49H56ClN7O5S3

954.66

CC(C)([C@@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)NC(CCCCCCCOC4=CC=CC=C4C5=CSC(C6=CSC(NC7=CC=C(Cl)C=C7)=N6)=N5)=O)C

Cytochrome P450; PROTACs

CYP1

Room temperature