PROTAC eDHFR Degrader-2 [CAS 2849442-91-5]

PROTAC eDHFR Degrader-2 (compound 7b) is a potent degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), enabling robust degradation of eDHFR-tagged proteins[1].

[2849442-91-5]

C34H40N8O9

704.73

NC1=C(CC2=CC(OC)=C(OCCCC(NCCOCCNC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C(OC)=C2)C=NC(N)=N1

Bacterial; PROTACs

10 mM in DMSO

Room temperature