PROTAC EZH2 Degrader-3 [CAS 3098718-46-5]

PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis ((Blue: cereblon ligand Pomalidomide , Black: linker HY-W361751; Pink: EZH2 inhibitor Tazemetostat (HY-13803) ).

[3098718-46-5]

C56H68N8O8

981.19

CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCN(C(CC5CCC(CNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)CC5)=O)CC4)C=C3)=CC(C(NCC9=C(C)C=C(C)NC9=O)=O)=C2C

Apoptosis; Histone Methyltransferase; PROTACs

Room temperature