PROTAC IRAK4 degrader-10 [CAS 3033829-95-4]

PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note: (Blue: Cereblon ligand, Black: linker; Pink: IRAK4 ligand) [1].

[3033829-95-4]

C43H45F3N8O6

826.86

O=C(C1=NC(C2C(F)(F)C2)=CC=C1)NC3=CN4C(C(F)=C3C(C)(O)C)=NC(C5CCN(CC6CCN(C7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)CC6)CC5)=C4

IRAK; PROTACs

Room temperature