PROTAC IRAK4 degrader-11

PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC50 of 2.29 nM in HEK293 cells (Sturcture Note: (Blue: Cereblon ligand , Black: linker; Pink: IRAK4 inhibitor).

C41H41F3N8O6

798.81

O=C(C1=CC=CC([C@@H]2CC2(F)F)=N1)NC3=CN4C=C(C5CCN(CC6CN(C6)C7=CC=C8C(N(C9C(NC(CC9)=O)=O)C(C8=C7)=O)=O)CC5)N=C4C(F)=C3C(C)(C)O

IRAK; PROTACs

Room temperature