PROTAC MDM2 Degrader-2 [CAS 2249944-99-6]

PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader. PROTAC MDM2 Degrader-2 can induce the self-ubiquitination and degradation of MDM2, thereby upregulating the level of p53 protein. PROTAC MDM2 Degrader-2 has anti-tumor activity and can be used in the study of cancer[1]. (Blue: MDM2 ligand ; Black: linker (HY-128833) )

[2249944-99-6]

C70H76Cl4N10O12

1391.22

O=C(N1CC(N(CC(NCCOCCOCCNC(CN2C(CN(C(N3[C@@H](C4=CC=C(Cl)C=C4)[C@@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@@H](C8=CC=C(Cl)C=C8)[C@@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

E1/E2/E3 Enzyme; MDM-2/p53; PROTACs

MDM2

96.01

DMSO : 50 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice