PROTAC PAPD5 degrader 1

PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo[1], with IC50 and CC50 of 10.59 μM and > 50 μM, respectively in Huh7 cells[1].

C49H63N5O16

978.05

O=C(C1=CN([C@H](C(C)C)CC2=C3C=C(OC)C(OCCCNC(CCOCCOCCOCCOCCOCCOCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=C2)C3=CC1=O)O

HBV; PROTACs

10 mM in DMSO

Room temperature