PROTAC PDIA1 degrader 1 [CAS 3024292-21-2]

PROTAC PDIA1 degrader 1 (Compound H4) is a PDIA1 PROTAC degrader with a DC50 of 29.71 μM. PROTAC PDIA1 degrader 1 has potent anticancer activity and significantly inhibits cancer cell proliferation[1]. Pink: PDIA1 ligand ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker (HY-W015088)

[3024292-21-2]

C40H44N6O12S

832.88

COC1=C(N(C(C#C)=O)C(C(NCC(NCCOCCOCCOCCNC2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C5=CC=CS5)C=CC(OC)=C1

PDI; PROTACs

Room temperature