PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 ; Black: linker (HY-W014787) ; Blue: ligand for VHL E3 ligase (S, R, S) -AHPC (HY-125845) )

C55H74BrN11O5S

1081.22

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCC(N2CCN(C3=CC=C(C4=NC5=C(NC6CCN(CC)CC6)C(Br)=CN=C5N4)C=C3)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7

Apoptosis; PROTACs; ROR

Room temperature