PROTAC SMARCA2/4-degrader-17 [CAS 2568276-88-8]

PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1]

[2568276-88-8]

C51H57N11O5S

936.13

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=C(C=C(C=C6)CC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C)C=N5)C(CC4)C3

Epigenetic Reader Domain; PROTACs

Room temperature